Cover Picture: Expanding the Toolbox of Target Directed Bio‐Orthogonal Synthesis: <i>In Situ</i> Direct Macrocyclization by DNA Templates (Angew. Chem. Int. Ed. 7/2023)

The DNA-templated bioorthogonal synthesis of macrocyclic gene modulators is illustrated in the cover picture accompanying Research Article (e202215245) by Jyotirmayee Dash and co-workers. DNA secondary structures present telomere oncogene promoter proximally orient bifunctional alkyne azide fragments, enabling bond formation copper-free azide–alkyne cycloaddition live cells. high-affinity binding ligand efficiently suppresses expression cancer Electrooxidation Zinc-Ion Batteries Nanographenes Metal–Organic Frameworks